Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
A Mendelian randomization study of genetic predisposition to autoimmune diseases and COVID-19Article Published on 2022-10-212022-11-16 Journal: Scientific Reports [Category] 변종, [키워드] Analysis Antigen association Autoimmune disease Autoimmune diseases biliary cirrhosis concern coronavirus disease COVID-19 COVID-19 susceptibility Diabetes Mellitus disease examined Genetic predisposition Genetic variant Genome-wide association studies Genome-wide association study hospitalized COVID-19 immune response Infection juvenile idiopathic arthritis leukocyte mendelian randomization Mendelian randomization analysis multiple sclerosis performed rheumatoid arthritis severe COVID-19 severity severity of COVID-19 similarities susceptibility systemic lupus erythematosus with COVID-19 [DOI] 10.1038/s41598-022-22711-1 PMC 바로가기
Obesity, Hypovitaminosis D, and COVID-19: the Bermuda Triangle in Public Health비만, 비타민 D 부족 및 COVID-19: 공중 보건의 버뮤다 삼각지대Review Published on 2022-09-012022-09-11 Journal: Current obesity reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome association body mass body mass index convergence COVID-19 COVID-19 pandemic COVID-19 susceptibility death Evidence explain Genetic genetic data genetic evidence Genome-wide association studies Genome-wide association study higher risk highlighting Hospitalization hypovitaminosis Hypovitaminosis D independent risk factor Infectious complications measure morbidity and mortality obesity outcomes pandemic Pandemics potential mechanism potential mechanisms Prevalence prevalent Public public health recent required respiratory distress risk risk factor robust SARS-CoV-2 SARS-COV-2 infection severe disease severity Severity of disease shown subject suggested syndrome therapeutic Treatment treatment of COVID-19 Triangle Vitamin D vitamin D level vitamin D levels Vitamin D supplementation vitamin D. [DOI] 10.1007/s13679-022-00471-3 PMC 바로가기 [Article Type] Review
Host genomics of SARS-CoV-2 infectionSARS-CoV-2 감염의 숙주 유전체학Review Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] acute infection approach approaches association Asymptomatic causal variant complications COVID-19 COVID-19 pneumonia demographic disease disease severity downstream Exome explain exploration Factor fraction functional genetic determinant genetic determinants Genetic variant Genome sequencing Genome-wide association studies genomic study highlighting host-virus interactions Human human genetic variation immune function individuals International involved life-threatening locus management Mild outcome pandemic Pathogenesis pathway Pathways Pneumonia Region required SARS-CoV-2 SARS-CoV-2 infected individuals SARS-COV-2 infection SARS-CoV-2 pathogenesis severe cases shown therapeutic targets type I interferon type I interferon response Variability with COVID-19 [DOI] 10.1038/s41431-022-01136-4 PMC 바로가기 [Article Type] Review
The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune ResponsesCOVID-19 중증도에 대한 유전적 위험은 면역 반응의 결함과 관련이 있습니다Article Published on 2022-05-122022-09-11 Journal: Frontiers in Immunology [Category] 변종, [키워드] ABO association Blood Group cohorts COVID-19 COVID-19 patient cytokine dataset disease disease severity Endothelial dysfunction European functional Functional genomics genetic loci genetic risk genetic susceptibility Genetic variant Genome genome-wide association Genome-wide association studies Genome-wide association study Genomics genotyping GWASs Host Human immune responses immunological independent individual innate immune response pathway Pathways physiological protein level protein levels recent response severe COVID-19 severe disease significantly single-cell single-cell. susceptibility therapy transcript von Willebrand factor vWF [DOI] 10.3389/fimmu.2022.859387 PMC 바로가기 [Article Type] Article
Shared genomic architectures of COVID-19 and antisocial behaviorCOVID-19의 공유 게놈 구조와 반사회적 행동Article Published on 2022-05-102022-09-11 Journal: Translational Psychiatry [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggression antisocial antisocial behavior average average income baby calculate cause chronic obstructive chronic obstructive pulmonary disease coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 Diseases estimate exposure to false-discovery rate Genetic genetics Genome-wide association studies Genome-wide association study genomic Health higher risk Linkage disequilibrium matrix measure mind obstructive pulmonary disease omicron overlap pandemic pulmonary disease SARS-CoV-2 severe acute respiratory syndrome Coronavirus text traits Vaccine variant verbal with COVID-19 [DOI] 10.1038/s41398-022-01948-4 PMC 바로가기 [Article Type] Article
The human genetic epidemiology of COVID-19Review Published on 2022-05-022023-06-15 Journal: Nature reviews. Genetics [Category] COVID19(2023년), MERS, SARS, [키워드] Disease genetics Genetic variation Genome-wide association studies Pathogens SARS-CoV-2 [DOI] 10.1038/s41576-022-00478-5 PMC 바로가기 [Article Type] Review
Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages단핵구 및 대식세포의 케모카인 수용체 유전자 조절과 관련된 심각한 COVID-19 관련 변이체Article Published on 2022-04-142022-09-11 Journal: Genome Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] 3D genome organization 3p21.31 association CCR1 CCR2 CCR5 Chemokine receptor chromatin Control COVID-19 CTCF elevated epigenomic Gene regulation Genes Genetic genetic association Genome Genome-wide association studies GWAS hallmark Hospitalization increased expression infiltration inflammatory monocyte inflammatory monocytes locus Macrophage macrophages mechanism monocyte Monocytes organ rationale Regulatory regulatory element risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. severe COVID-19 SNP variant [DOI] 10.1186/s13059-022-02669-z PMC 바로가기 [Article Type] Article
Elevated plasma levels of CXCL16 in severe COVID-19 patients중증 COVID-19 환자에서 CXCL16의 혈장 수준 상승Clinical Trial Published on 2022-04-012022-09-11 Journal: Cytokine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, [키워드] association baseline benefit Cell cellular chemotaxis clinical trial Cohort collected controls COVID-19 CXCL16 CXCR6 defined determine disease elevated Genome-wide association studies homing hospitalized COVID-19 patient hospitalized patient hospitalized patients Immunopathogenesis Injury interact Ligand locus lung Lung infection Lungs motif P-value Pathogenesis Patient plasma plasma concentration plasma concentrations Plasma levels reported risk severe COVID-19 severe COVID-19 patient severity of COVID-19 Support susceptibility T cell T cells variant were assessed WHO Whole genome sequencing whole genome sequencing. whole-genome sequencing [DOI] 10.1016/j.cyto.2022.155810 PMC 바로가기 [Article Type] Clinical Trial
Shared genomic architecture between COVID-19 severity and numerous clinical and physiologic parameters revealed by LD score regression analysisArticle Published on 2022-02-032022-10-04 Journal: Scientific Reports [Category] MERS, 바이오마커, 유전자 메커니즘, [키워드] analyses Analysis Apolipoprotein A association associations asymptomatic infection attenuate Biomarker Blood BMI clinical evaluation clinical manifestations conducted correlation COVID-19 pandemic COVID-19 severity death diabete Epidemiology Genetic genetic architecture Genetic predisposition to disease Genome-wide association studies genomic genomic region HDL Hospitalization Linkage disequilibrium Mendelian randomization study parameter parameters Phenotypes positive produced Protective provide regression analysis Removing Research retinol risk factor robust sensitivity analysis severe COVID-19 Shortness of breath smoking therapeutic target [DOI] 10.1038/s41598-022-05832-5 PMC 바로가기 [Article Type] Article